Updated May 20, 2018 12:01:33 The amount of ultraviolet radiation reaching the human skin is estimated to be about 300 times higher than the level at which the skin starts to lose its protective barrier.
Now, new research from the University of Newcastle has revealed that ultraviolet radiation also damages the skin’s DNA, making it more susceptible to UV damage.
UV light is known to cause skin cancer in humans, and research has linked it to skin ageing and increased risk of melanoma.
A research team from Newcastle has used a mouse model of skin cancer to test how UV light impacts the DNA of the skin, and has shown that UV light can damage the DNA in the human genome.
The study was published in Nature Nanotechnology.
“It was really exciting to find that UV radiation can affect the DNA, even in a mouse, and it can do this at a level that is not seen with conventional UV radiation,” Professor Michael Litt, one of the study’s lead authors, said.
“This is a real breakthrough and is important to understand the biological mechanisms of UV damage.”
Professor Litt said the research was particularly exciting because UV radiation is known as a risk factor for skin cancer.
“We know that UV exposure causes damage to the DNA and that DNA damage can lead to changes in cell proliferation, migration and differentiation of the cells.”
The more we know about UV damage in humans the more we need to consider the potential for this to be an issue in humans.
UV radiation damage to DNA was first identified in the 1970s. “
What we’ve shown in this study is that UV has an impact on the DNA by causing changes in DNA and it’s not just skin, it’s all cells in the body,” Professor Ruggs said.
UV radiation damage to DNA was first identified in the 1970s.
The research team has now been able to show that the same process can occur in the mouse model, which has also been shown to affect other cells, including cancer cells.
“There are a number of other studies that have shown that the DNA changes are similar to those that we see in humans,” Professor Lett said.
Professor Litte said the findings from the mouse study suggested that there was a potential for a human-specific mechanism of UV-induced damage to be activated.
“The study has shown a possible mechanism for how the UV light damage is causing these changes in the DNA,” Professor Niamh O’Connor, from the Newcastle Institute for Biomedical Research, said in a statement.
“Our research shows that there is a potential that UV is changing the DNA on a molecular level and this could be the basis for some of the human cancers.”
Professor Riddell said the study had important implications for the future.
“A major limitation of this study was that we could not directly compare UV light to UV radiation.
This is a really important area of future research,” he said.