How to use ultraviolet to kill all mutations of UV is no longer just a theoretical science fiction idea, as researchers are now using the technology to eradicate the UV-induced skin cancer in mice.
The research, led by Dr. Rolf de Groot of the University of Copenhagen and published in the journal PLOS ONE, demonstrates how the sun’s UV radiation can damage and kill cells of the skin.
It is hoped that the discovery will pave the way for more effective therapies for skin cancer.
“Ultraviolet light is a key factor that causes UV-associated skin cancer, and it is now well understood that ultraviolet light causes DNA damage in the skin,” said Dr. de Groote.
“Our study shows that UV light can damage DNA and can also be used as a potential therapy to eliminate mutations in the melanoma cells in mice.”
A mutation of the gene that controls the production of melanin in the hair follicles of mice is found to be a key driver of the development of melanoma.
This mutation is found in less than 10 percent of Caucasians.
The mutations in melanoma have also been found to increase in frequency in Asian populations, and they have also increased in frequency and extent in African populations.
In the past, ultraviolet light has been shown to destroy the melanin cells in hair follicle cells, but this has not been enough to completely eliminate the cancerous melanoma, and melanoma is still found in about 1 percent of Caucasian people.
Dr. De Groot and his team wanted to find a way to stop melanoma from becoming a more common form of skin cancer and to prevent melanoma mutations from occurring.
The researchers used ultraviolet light to attack the melanocytes of hair follicular cells, in this case melanoma melanoma microangioma.
They then injected the cells with a chemical known as a tumor necrosis factor, which mimics the effect of ultraviolet light, and then used the chemicals to remove melanoma cell DNA.
“In this study, we show that ultraviolet irradiation, through a combination of light, DNA, and the drug, can eliminate melanoma-derived DNA from hair follicicles and also eliminate mutations of the melanocortin-4 receptor gene in melanocontin-3 melanoma,” said De Groote, “and also prevent melanocondyloma from growing.”
The results are promising for future melanoma therapies that can eliminate mutations that can lead to the growth of melanomas, which have been identified as the most dangerous form of cancer in humans.
“The goal is to use the same UV light that is present in the sun to treat cancer, as a new and more effective therapy,” Dr. Pauline De Grootte, who is also a researcher in the research team, said.
Dr. De Greot and her colleagues are now planning to test this treatment on humans, and hope to be able to identify which mutations are the most lethal for melanoma patients.
“We are looking forward to seeing how long it will take for these treatments to be tested in human patients,” Dr De Groots team said in a press release.
“We hope to develop a more effective cancer treatment to reduce the number of melanocarene mutations that are present in melanomas.”